BCKDK Antibody

中文名稱：

BCKDK兔多克隆抗體
貨號：

CSB-PA182563
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from 293 cells and Jurkat cells, using BCKD antibody.

Immunofluorescence analysis of HeLa cells, using BCKD antibody.
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) BCKDK Polyclonal antibody
Uniprot No.：

O14874
基因名：

BCKDK
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Internal of Human BCKD.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
基因功能參考文獻(xiàn)：
1. our study indicates that BCKDK promotes colorectal tumorigenesis through up-regulation of the MAPK signaling pathway by phosphorylating MEK at Ser221. PMID: 28501528
2. There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
3. Results demonstrate that BCKDK mutations can result in neurobehavioral deficits in humans. PMID: 24449431
4. This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information. PMID: 15302860
5. employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD) PMID: 11839747
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相關(guān)疾病：

Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)
亞細(xì)胞定位：

Mitochondrion matrix. Mitochondrion.
蛋白家族：

PDK/BCKDK protein kinase family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 16902

OMIM: 614901

KEGG: hsa:10295

STRING: 9606.ENSP00000219794

UniGene: Hs.513520