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GIPR

GIPR,即胃抑制多肽受體,別名PGQTL2。GIPR由人類GIPR基因編碼,該基因位于19號染色體的q13.32區域。GIPR是一種G蛋白偶聯受體,其內源性配體為葡萄糖依賴性促胰島素釋放多肽(GIP),在脂肪生成、胰島β細胞增殖和胰島素釋放等方面發揮重要作用,與2型糖尿病、肥胖癥和神經退行性疾病相關。
GIPR與GIP結合后可激活腺苷酸環化酶-環磷酸腺苷-蛋白激酶A通路,促進胰島素分泌。GIPR在調節餐后血糖濃度中起到關鍵作用,在高血糖條件下促進胰島素的分泌;在低血糖條件下刺激胰島α細胞釋放胰高血糖素,從而維持血糖穩態。GIPR的異常表達或功能失調可能與糖尿病的發病機制相關,是糖尿病治療的潛在靶點。

熱銷產品

Recombinant Macaca fascicularis Gastric inhibitory polypeptide receptor (GIPR), partial (Active) (CSB-YP4825MOV)

驗證數據

CSB-YP4825MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-YP4825MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GIPR at 2μg/mL can bind Anti-GIPR recombinant antibody (CSB-RA009438MA1HU),the EC50 is 12.66-13.86 ng/mL.

Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial (Active) (CSB-MP009438RA1)

驗證數據

CSB-MP009438RA1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009438RA1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat Gipr at 2μg/mL can bind Anti-Mouse Gipr recombinant antibody (CSB-RA009438MA1MO), the EC50 is 26.97 - 33.90 ng/mL.

Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active) (CSB-MP009438MO1)

驗證數據

CSB-MP009438MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009438MO1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Gipr at 2μg/mL can bind Anti-Mouse Gipr recombinant antibody (CSB-RA009438MA1MO), the EC50 is 8.622-11.36 ng/mL.

Recombinant Human Gastric inhibitory polypeptide receptor(GIPR),partial (Active) (CSB-MP009438HU1d7)

驗證數據

CSB-MP009438HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009438HU1d7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GIPR at 2μg/mL can bind Anti-GIPR recombinant antibody (CSB-RA009438MA1HU),the EC50 is 16.18-18.70 ng/mL.

CSB-MP009438HU1d7

The purity of GIPR was greater than 95% as determined by SEC-HPLC

GIPR Recombinant Monoclonal Antibody (CSB-RA009438MA1HU)

驗證數據

CSB-RA009438MA1HU

The Binding Activity of Macaca fascicularis GIPR with Anti-GIPR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GIPR (CSB-YP4825MOV) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 12.66-13.86 ng/mL.

CSB-RA009438MA1HU

The Binding Activity of Human GIPR with Anti-GIPR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GIPR (CSB-MP009438HU1d7) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 16.18-18.70 ng/mL.

GIPR Antibodies

GIPR for Homo sapiens (Human)

GIPR for Mus musculus (Mouse)

GIPR Proteins

GIPR Proteins for Rattus norvegicus (Rat)

GIPR Proteins for Homo sapiens (Human)

GIPR Proteins for Mesocricetus auratus (Golden hamster)

GIPR Proteins for Mus musculus (Mouse)

GIPR Proteins for Mus musculus (Mouse)