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  4. STX16 Recombinant Monoclonal Antibody

STX16 Recombinant Monoclonal Antibody

  • 中文名稱：
    STX16 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA027547A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA027547A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    STX16
  • 別名：
    hsyn16 antibody; MGC90328 antibody; Stx16 antibody; STX16_HUMAN antibody; Syn16 antibody; Syntaxin-16 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide from human STX16 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    17B11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
  • 基因功能參考文獻(xiàn)：
    1. we here present a patient with PHP1b caused by a recurrent STX16 deletion, presenting with macrosomia, early onset obesity, and macrocephaly without other AHO symptoms. we reemphasize STX16 deletions and PHP1b as a rare cause for early onset obesity and macrosomia. PMID: 27338644
    2. STX16 microdeletion was identified in male monozygotic twins (with pseudohypoparathyroidism type 1B leading to growth hormone deficiency) and mother/grandmother (not father/grandfather or sister [their triplet with separate placenta]). [CASE STUDY] PMID: 25843330
    3. syntaxin 16 is a key regulator of cytokinesis. PMID: 24109596
    4. A patient with familial pseudohypoparathyroidism type Ib and his asymptomatic brother were found to have methylation defect at GNAS (guanine nucleotide-binding protein G) and microdeletion involving exons 4-6 of neighboring gene STX16. [CASE REPORT] PMID: 23095209
    5. De novo 3-kb STX16 deletions, reported only once previously, are infrequent but should be excluded in all cases of Pseudohypoparathyroidism-Ib, even when the family history is negative for an inherited form of this disorder. PMID: 23087324
    6. Results suggest that STX16 mediates recycling of CFTR and constitutes an important component of CFTR trafficking machinery in intestinal epithelial cells. PMID: 20826815
    7. the region of overlap between the two microdeletions likely harbors a cis-acting imprinting control element that is necessary for establishing and methylation at GNAS exon A/B, thus allowing normal G alpha(s) expression in the proximal renal tubules. I PMID: 15800843
    8. function of syntaxin 16 was specifically required for, and restricted to, the retrograde pathway PMID: 17389686
    9. Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic. PMID: 17852734
    10. phosphorylation of RASSF1A by Aurora B is required for the recruitment of Syntaxin16 PMID: 19887622

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  • 相關(guān)疾病：
    Pseudohypoparathyroidism 1B (PHP1B)
  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type IV membrane protein.; [Isoform C]: Cytoplasm.
  • 蛋白家族：
    Syntaxin family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11431

    OMIM: 603233

    KEGG: hsa:8675

    STRING: 9606.ENSP00000360183

    UniGene: Hs.307913