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  4. GOLIM4 Recombinant Monoclonal Antibody

GOLIM4 Recombinant Monoclonal Antibody

  • 中文名稱：
    GOLIM4 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA290018A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of golgi integral membrane protein 4 expression in HAP-1 cells using golgi integral membrane protein 4 antibody. Green, isotype control; red, golgi integral membrane protein 4.
    • Immunocytochemical staining of HAP-1 cells with Golgi integral membrane protein 4 antibody. Nuclei were stained blue with DAPI; Golgi integral membrane protein 4 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.
    • Western blotting analysis using golgi integral membrane protein 4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with golgi integral membrane protein 4 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    GOLIM4
  • 別名：
    GOLIM4; Golgi Integral Membrane Protein 4; GPP130; GIMPC; Golgi Phosphoprotein 4; GOLPH4; P138; Golgi-Localized Phosphoprotein Of 130 KDa; Golgi Integral Membrane Protein, Cis; Golgi Phosphoprotein Of 130 KDa; Cis Golgi-Localized Calcium-Binding Protein; 130 KDa Golgi-Localized Phosphoprotein; Type II Golgi Membrane Protein; GIMPc
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human GOLIM4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    7H11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
  • 基因功能參考文獻：
    1. Authors provide evidence that Mn-induced exit of GPP130 from the trans-Golgi network (TGN) toward lysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP130. PMID: 28768823
    2. Findings suggest the unexpected presence of quality control in the Golgi that recognizes aggregated Golgi proteins, GPP130, and targets them for degradation in lysosomes. PMID: 26446839
    3. Characteristics of GPP130 and its STx/STx1 binding interface. PMID: 23761068
    4. the stem domain of GPP130 is a novel Mn sensor in the Golgi lumen of mammalian cells PMID: 20130081
    5. both the translation and transcription are regulated independent of the cell cycle and dissociated from the duplication of the centrosome PMID: 12207053
    6. GPP130 mediates exit from endosomes and thereby underlies Shiga toxin invasion and retrieval-based targeting of other cycling Golgi proteines PMID: 15331763
    7. Multiple pH-regulated steps affect the trafficking of GPP130. PMID: 17605763

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  • 亞細胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
  • 蛋白家族：
    GOLIM4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15448

    OMIM: 606805

    KEGG: hsa:27333

    STRING: 9606.ENSP00000417354

    UniGene: Hs.143600