RNF170 Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

Uniprot No.：

Q96K19
基因名：

RNF170
別名：

RNF170; E3 ubiquitin-protein ligase RNF170; Putative LAG1-interacting protein; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human RNF170
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
基因功能參考文獻(xiàn)：
1. aberrant ubiquitination of substrates, or cellular adaptation to chronically reduced RNF170 levels likely accounts for the autosomal dominant sensory ataxia-associated Ca2+ signaling deficit PMID: 25882839
2. RNF170 plays an essential role in IP(3) receptor processing via the ubiquitin-proteasome pathway. PMID: 21610068
3. Together these results suggest that the mutation in RNF170 is causal for the sensory ataxia PMID: 21115467
相關(guān)疾病：

Ataxia, sensory, 1, autosomal dominant (SNAX1)
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Expressed in the spinal chord.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 25358

OMIM: 608984

KEGG: hsa:81790

STRING: 9606.ENSP00000434797

UniGene: Hs.491626