Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
基因功能參考文獻:
KLK6 may be the key protease involved in the proteolytic modification of PFK-M. PMID: 29563071
characterize three PFK1 mutations and show they have distinct effects on allosteric regulation of PFKP activity and lactate production. PMID: 25985179
Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6). PMID: 24493630
insulin/phosphofructokinase (PFKM), overlaps with an expression quantitative trait loci PMID: 24306210
Asp(543)Ala, a naturally occurring Tarui disease-causing mutation in the activating binding site, causes an increased efficacy of ATP at the inhibitory allosteric binding site. PMID: 22995305
Molecular genetic findings demonstrated the absence of specific genotype-phenotype correlations in PFKM gene mutations. PMID: 22133655
eukaryotic Pfk did not evolve from prokaryotic ancestors, reciprocal linkage of functionally opposed allosteric binding sites must have developed independently in prokaryotic and eukaryotic Pfk (convergent evolution). PMID: 22474333
Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors PMID: 21573193
Data indicate that substitution of residue at the citrate-binding site (D591V) of PFK-M resulted in the complete loss of activity. PMID: 21124851
Glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFK-L over the M and P isoforms. PMID: 20483646
Identification of novel PFK-M transcripts in the testis and embryo. PMID: 15020257
Two phosphofructokinase (PFK) chimeras were constructed by exchanging the N- and C-terminal halves of the mammalian M- and C-type isozymes. PMID: 17544406
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相關疾病:
Glycogen storage disease 7 (GSD7)
亞細胞定位:
Cytoplasm.
蛋白家族:
Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade "E" sub-subfamily