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  4. NPTN Antibody

NPTN Antibody

  • 中文名稱：
    NPTN兔多克隆抗體
  • 貨號：
    CSB-PA008837
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NPTN
  • 別名：
    GP55 antibody; GP65 antibody; Neuroplastin antibody; np55 antibody; np65 antibody; Nptn antibody; NPTN_HUMAN antibody; SDFR1 antibody; SDR-1 antibody; SDR1 antibody; stromal cell derived factor receptor 1 antibody; Stromal cell-derived receptor 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Neuroplastin.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.
  • 基因功能參考文獻：
    1. Cryoelectron microscopy structure offers important insight into how the NPTN binds to the PMCA1. PMID: 30190470
    2. Xkr8-BSG/NPTN complex is required for phosphatidylserine scrambling in apoptotic cell membranes. PMID: 27503893
    3. This study showed that Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. PMID: 24514566
    4. correct synaptic membrane protein localization, neuronal energy supply, expression of LTP and LTD, animal and human behaviour, and pathophysiology and disease--{review} PMID: 25040546
    5. NPTN may be involved in genetic susceptibility to schizophrenia. PMID: 17123723
    6. In human brain np65 is prominently present in cerebellum while np55 is the predominant isoform in mouse and rat cerebellum. PMID: 17196182

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell junction, synapse, postsynaptic density.
  • 組織特異性：
    Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).
  • 數據庫鏈接：

    HGNC: 17867

    OMIM: 612820

    KEGG: hsa:27020

    STRING: 9606.ENSP00000290401

    UniGene: Hs.744867