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  4. KREMEN1 Antibody

KREMEN1 Antibody

  • 中文名稱：
    KREMEN1兔多克隆抗體
  • 貨號：
    CSB-PA850397ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA850397ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA850397ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KREMEN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AV002070 antibody; Dickkopf receptor antibody; KREM1_HUMAN antibody; KREMEN antibody; Kremen protein 1 antibody; Kremen protein 1 precursor antibody; Kremen1 antibody; Kringle coding gene marking the eye and the nose antibody; Kringle containing protein marking the eye and the nose antibody; Kringle containing transmembrane protein 1 antibody; Kringle containing transmembrane protein antibody; Kringle domain containing transmembrane protein 1 antibody; Kringle domain-containing transmembrane protein 1 antibody; Kringle-containing protein marking the eye and the nose antibody; KRM1 antibody; RP23 293J16.1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kremen protein 1 protein (180-380AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
  • 基因功能參考文獻：
    1. Structure of the dual-mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and DKK1 have been presented. PMID: 27524201
    2. Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C). PMID: 27049303
    3. Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding or by cancer mutations. PMID: 26206087
    4. Six Dkk-1, three Sost, one Kremen-1 and 10 LRP-5 polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction. PMID: 23041840
    5. This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population. PMID: 20153141
    6. Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6 PMID: 18502762
    7. Functional characterization of related Kremen proteins in mouse. PMID: 12050670

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  • 相關疾病：
    Ectodermal dysplasia 13, hair/tooth type (ECTD13)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：

    HGNC: 17550

    OMIM: 609898

    KEGG: hsa:83999

    STRING: 9606.ENSP00000331242

    UniGene: Hs.229335