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  4. GRM7 Antibody

GRM7 Antibody

  • 中文名稱：
    GRM7兔多克隆抗體
  • 貨號：
    CSB-PA618911ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA618911ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GRM7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ40498 antibody; GLUR7 antibody; Glutamate receptor metabotropic 7 antibody; GPRC1G antibody; GRM7 antibody; GRM7_HUMAN antibody; Metabotropic glutamate receptor 7 antibody; MGLU7 antibody; mGluR7 antibody; OTTHUMP00000206961 antibody; OTTHUMP00000214674 antibody; OTTHUMP00000214675 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Metabotropic glutamate receptor 7 protein (220-410AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
  • 基因功能參考文獻：
    1. The mutant allele C in rs1485175 of the GMR7 may decrease individuals' susceptibility to noise-induced hearing loss. PMID: 29301492
    2. The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population. PMID: 28027116
    3. study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample PMID: 27788777
    4. Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway. PMID: 27312574
    5. GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia. PMID: 26856250
    6. Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits. PMID: 26866891
    7. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population PMID: 26655190
    8. Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
    9. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population. PMID: 26254163
    10. results reported here do not support a role for GRM7 in ADHD PMID: 25360607
    11. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder. PMID: 24804643
    12. For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4, we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS PMID: 24278217
    13. in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns. PMID: 24146964
    14. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population PMID: 23295062
    15. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults. PMID: 23102807
    16. SNPs in autism spectrum disorders PMID: 23201551
    17. Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population. PMID: 20078931
    18. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication. PMID: 21572164
    19. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). PMID: 21572167
    20. Data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain. PMID: 21813496
    21. we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons PMID: 21255632
    22. As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in age-related hearing impairment, this study provides further evidence for the involvement of this gene. PMID: 20068591
    23. Identified additional splicing variants involving the 3' end of the GRM7 coding sequence and resulting in three putative novel isoforms. PMID: 12052533
    24. The results of this study support the possible association of a GRM7 gene polymorphism with genetic susceptibility to schizophrenia. PMID: 18329248
    25. GRM7 contributes to risk of developing age-related hearing impairment. PMID: 19047183
    26. Study results provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. PMID: 19638256

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
  • 數據庫鏈接：

    HGNC: 4599

    OMIM: 604101

    KEGG: hsa:2917

    STRING: 9606.ENSP00000350348

    UniGene: Hs.606393