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  4. Fcmr Antibody

Fcmr Antibody

  • 中文名稱：
    Fcmr兔多克隆抗體
  • 貨號：
    CSB-PA007972LA01MO
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Fcmr antibody at 2µg/ml
      Lane 1: Rat spleen tissue
      Lane 2: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 48 kDa
      Observed band size: 48 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Fcmr Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Fcmr
  • 別名：
    Fcmr antibody; Faim3 antibody; TosoFas apoptotic inhibitory molecule 3 antibody; IgM Fc fragment receptor antibody; Regulator of Fas-induced apoptosis Toso antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse, Rat
  • 免疫原：
    Recombinant Mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，Fcmr Antibody (CSB-PA007972LA01MO)，的標記方式是Non-conjugated。對于Fcmr Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007972LB01MO Fcmr Antibody, HRP conjugated ELISA
    FITC CSB-PA007972LC01MO Fcmr Antibody, FITC conjugated
    Biotin CSB-PA007972LD01MO Fcmr Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 基因功能參考文獻：
    1. Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection. PMID: 25257173
    2. these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice. PMID: 24994818
    3. FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge. PMID: 23267023
    4. Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis PMID: 24398517
    5. Toso is a unique regulator of innate immune responses during bacterial infection and septic shock. PMID: 23359703
    6. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
    7. mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis. PMID: 15632112

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  • 亞細胞定位：
    Membrane; Single-pass membrane protein.
  • 數據庫鏈接：