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  4. Cleaved-EFNA2 (N188) Antibody

Cleaved-EFNA2 (N188) Antibody

  • 中文名稱：
    Cleaved-EFNA2 (N188)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA000043
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using Cleaved-Ephrin-A2 (N188) Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    EFNA 2 antibody; efna2 antibody; EFNA2_HUMAN antibody; ELF1 antibody; Eph related receptor tyrosine kinase ligand 6 antibody; EPH-related receptor tyrosine kinase ligand 6 antibody; Ephrin-A2 antibody; EphrinA2 antibody; EPLG6 antibody; HEK7 L antibody; HEK7 ligand antibody; HEK7-L antibody; HEK7L antibody; LERK 6 antibody; LERK-6 antibody; LERK6 antibody; Ligand of eph related kinase 6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Ephrin-A2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
  • 基因功能參考文獻(xiàn)：
    1. Ephrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression PMID: 26561474
    2. these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry PMID: 24550731
    3. High EphA2 receptor expression in colorectal cancer was associated with a worse outcome in patients treated with cetuximab-based therapy PMID: 24050852
    4. Implicate EphA2 as a novel proinflammatory mediator and potential regulator of atherosclerotic plaque development. PMID: 22247258
    5. Optic nerve section in adult rat differentially regulates the expression of ephrin-A2 in the superior colliculus(SC).At 1 month, levels were upregulated across the contralateral SC giving rise to an increasing rostro-caudal gradient. PMID: 11860487
    6. Different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation. PMID: 11884456
    7. Abnormal posttranslational mechanisms of the Elf-1 protein result in defective expression of the functional 98-kDa form of Elf-1, and consequently, the transcriptional defect of TCR zeta-chain in patients with systemic lupus erythematosus. PMID: 12421992
    8. There is a significant loss of ELF-1 and reduced Smad4 expression in gastrointestinal neoplasms. PMID: 16158060
    9. Elf-1 represents the first transcription factor identified to be involved in the transcriptional regulation of Fc receptor gamma PMID: 17878388

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Ephrin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3222

    OMIM: 602756

    KEGG: hsa:1943

    STRING: 9606.ENSP00000215368

    UniGene: Hs.741510