The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA033129(CRH Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
基因功能參考文獻:
Early-preterm birth showed a syndrome of high maternal CRH and low vitamin D status. PMID: 28780891
REVIEW: CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response PMID: 28260504
REVIEW: Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract PMID: 28240194
REVIEW: The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response PMID: 28103784
Significant effects of CNS sensitization on CRF mRNA levels were detected in the Dorsal Striatum (increasing effect). PMID: 29857328
These results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents. PMID: 29277323
Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin; these interactions appear to be altered in patients with pituitary disease; copeptin may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases. PMID: 28795329
The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of the CRH family members. The purpose of this review is to summarize the most significant discoveries related to CRH over time. [review] PMID: 28071586
A significant increase in CRH and CRHR-1 expression was significantly correlated with psychological stress in vitiligo. PMID: 27663146
Corticotrophin-releasing hormone accelerated tumor angiogenesis by upregulating VEGF expression and secretion in colon cancer cells. PMID: 28618089
This study found that the expressions of CRH and CRHR1 were significantly higher in the epileptogenic tissues of patients with IS than in the control group. PMID: 27534449
The authors propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies. PMID: 28151936
Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest that women with PCOS exhibit reduction of CRH and NGF; reduction of CRH and NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (NGF = nerve growth factor) PMID: 27908212
brain activation in response to colorectal distention is enhanced after CRH injection in Irritable bowel syndrome patients compared to healthy controls PMID: 27448273
In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma. PMID: 27567427
In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients. PMID: 27754786
VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. PMID: 26818776
This study localized a complete CRF system in the human fetal heart. PMID: 27377597
Placenta CRH mRNA concentration appears to convey information about the risk of brain damage in the infant born at an extremely low gestational age. PMID: 26331704
These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status. PMID: 26882083
This study evaluated the associations of CRH polymorphisms with susceptibility to MDD and response to antidepressant treatment PMID: 26055202
results suggest that glucocorticoids induce a transcription complex consisting of RelB/p52, CBP, and HDAC1 that triggers a dynamic acetylation-mediated epigenetic change to induce CRH expression in full-term human placenta. PMID: 26307012
Interaction of RelB with the CRH or COX-2 gene promoters decreased when STAT3 was depleted. PMID: 25771405
the present study demonstrates that the expression of CRH/CRH-R1 in lesions of chronic plaque psoriasis is lower than that in psoriatic perilesional skin and normal control skin. PMID: 25630718
results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway PMID: 26350463
This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety PMID: 26212818
Placental CRH exposure may make a unique contribution to fetal programming of obesity risk. PMID: 25591114
Data suggest that signal transduction involving corticotropin-releasing factor (CRH) and CRH receptors (CRHR) taking place in cochlea are involved in protecting against noise-induced hearing loss. [REVIEW] PMID: 26074267
Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria. PMID: 25339828
we show that Abeta species can hyperexcite CRF neurons, providing a mechanism by which Abeta influences stress-related symptoms PMID: 25673853
High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient. PMID: 24985398
Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes. PMID: 24835211
Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF, which regulates NKG2D expression in natural killer cells. PMID: 24841552
This review focuses on the CRF receptor, a stress-related peptide implicated in diverse psychiatric and medical disorders that are more prevalent in females in diverse psychiatric and medical disorders that are more prevalent in females. PMID: 23849813
evidence suggests that CRH regulates neurogenesis in the brain. PMID: 23380766
as labor progresses, progesterone and corticotropin-releasing hormone increase and subsequently decrease precipitously in the immediate postpartal period PMID: 24597258
Data suggest that expression of CRF, CRF-related neuropeptides, and CRF receptors in the liver plays crucial regulatory roles in homeostasis, in allostasis to endogenous stresses, and in adaptation to exogenous stress stimuli. [REVIEW] PMID: 23933692
During the midluteal phase of the cycle, metformin may decrease the production of CRH and urocortin in the endometrium. PMID: 23987517
in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
IL-6 and CRH are both secreted in a pulsatile fashion during the active phase of human labor. The time-integrated concentrations of the two hormones are positively correlated, with IL-6 leading CRH secretion. PMID: 23928667
ERK1/2 activation in response to CRH is biphasic, involving a first cAMP- and B-Raf-dependent early phase and a second phase that critically depends on CRHR1 internalization and beta-arrestin2. PMID: 23371389
corticotrophin-releasing hormone (CRH) might play a significant role in the pathogenesis of intrahepatic cholestasis of pregnancy(ICP) and provide a new approach to further investigate the etiology of ICP PMID: 23478074
A novel CRH missense mutation (Pro30Arg) results in reduced levels of protein secretion in the short time thus suggesting that mutated people could present an altered capability to respond immediately to stress agents. PMID: 23593457
CRH/CRHR1 are involved in regulation of PGHS2 (prostaglandin-endoperoxide synthase 2) expression in myometrium before/during labor; these actions appear important in priming myometrium for labor and adaptive responses to inflammatory mediators. PMID: 23666959
Data suggest that CRF plays role in acute postinjury gut dysfunction; CRF is expressed in small bowel of elective/emergency gastrointestinal (GI) surgery patients with concomitant GI dysfunction; plasma CRF correlates with poor gastric emptying. PMID: 23466050
Postnatally stressed adult transgenic mice have decreased hippocampal nectin-3 levels, which could be attenuated by CRHR1 inactivation and mimicked by corticotropin-releasing hormone (CRH) overexpression in forebrain neurons. PMID: 23644483
the age-associated changes in the expression of CRH system components reflect an exaggerated stress response reaction, putting the aged skin continuously in a stress-like situation. PMID: 22533365
CRH may be involved in the pathogenesis of gastric cancer PMID: 23477585
study demonstrates that the HeLa cervical cancer cell line expresses CRH; additionally, CRH was shown to induce FasL expression PMID: 23076876
The aberrant expression of corticotropin-releasing hormone in pre-eclampsia may activate the FasL-positive decidual macrophages, impair the physiological turnover of extravillous trophoblasts, and eventually disturb placentation. PMID: 22763913
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亞細胞定位:
Secreted.
蛋白家族:
Sauvagine/corticotropin-releasing factor/urotensin I family