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  4. CEP68 Antibody

CEP68 Antibody

  • 中文名稱：
    CEP68兔多克隆抗體
  • 貨號：
    CSB-PA005246GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Centrosomal protein 68kDa antibody; Centrosomal protein of 68 kDa antibody; Cep68 antibody; CEP68_HUMAN antibody; FLJ25920 antibody; FLJ36750 antibody; KIAA0582 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human CEP68
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase.
  • 基因功能參考文獻：
    1. CEP68 is important in forming rootletin filaments that branch off centrioles and to modulate the thickness of rootletin fibers. PMID: 29463719
    2. It has been proposed that the archetypal linker protein Rootletin maintains centrosome cohesion in part through inhibition of VHL-mediated Cep68 degradation. PMID: 28089774
    3. The Cep68 protein level needs to be fine-tuned in order to ensure that its direct interactors, such as the microcephaly protein Cep215 and PCNT, function properly. PMID: 28578000
    4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
    5. C-terminal 300-400 amino acids of Cep68 are necessary to localize Cep68 to interphase centrosomes while C-terminal 400-500 amino acids might regulate Cep68 dissociation from centrosomes at mitotic onset. PMID: 25704143
    6. CEP68 gene variants may play an important role in MNSAID-UA susceptibility and, despite the different regulatory mechanisms involved depending on the specific affected organ, in the development of hypersensitivity reactions to NSAIDs. PMID: 24618698
    7. Findings imply that CEP68 could be a susceptible gene for aspirin intolerance in asthmatics. PMID: 21072201
    8. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516
    9. data suggest that Cep68 cooperates with rootletin and C-Nap1 in centrosome cohesion. PMID: 18042621

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 數據庫鏈接：

    HGNC: 29076

    OMIM: 616889

    KEGG: hsa:23177

    STRING: 9606.ENSP00000367229

    UniGene: Hs.709257