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  4. ARPIN Antibody

ARPIN Antibody

  • 中文名稱：
    ARPIN兔多克隆抗體
  • 貨號：
    CSB-PA773801LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25, 44 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA773801LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773801LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ARPIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARPIN
  • 別名：
    2610034B18Rik antibody; Actin related protein 2/3 complex inhibitor antibody; Arp2/3 inhibition protein antibody; ARPIN antibody; C15orf38 antibody; Chromosome 15 open reading frame 38 antibody; CO038_HUMAN antibody; Hypothetical protein LOC348110 antibody; MGC61550 antibody; RIKEN cDNA 2610034B18 antibody; UPF0552 protein C15orf38 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Arpin protein (1-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ARPIN Antibody (CSB-PA773801LA01HU)，的標記方式是Non-conjugated。對于ARPIN Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA773801LB01HU ARPIN Antibody, HRP conjugated ELISA
    FITC CSB-PA773801LC01HU ARPIN Antibody, FITC conjugated
    Biotin CSB-PA773801LD01HU ARPIN Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
  • 基因功能參考文獻：
    1. ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling. PMID: 28531800
    2. Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients PMID: 28293092
    3. Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins. PMID: 26774128
    4. Arpin downregulation may contribute to the initiation and development of breast cancer metastasis. PMID: 26648569
    5. Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis. PMID: 25892881

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  • 亞細胞定位：
    Cell projection, lamellipodium.
  • 蛋白家族：
    Arpin family
  • 數據庫鏈接：

    HGNC: 28782

    OMIM: 615543

    KEGG: hsa:348110

    STRING: 9606.ENSP00000350075

    UniGene: Hs.6734