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  4. CNDP2 Monoclonal Antibody

CNDP2 Monoclonal Antibody

  • 中文名稱：
    CNDP2 Monoclonal Antibody
  • 貨號：
    CSB-MA781365
  • 規格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of H9c2 cells with Carnosine dipeptidase 2 antibody. Nuclei were stained blue with DAPI; Carnosine dipeptidase 2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using carnosine dipeptidase 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with carnosine dipeptidase 2 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CNDP2 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CNDP2; Carnosine Dipeptidase 2; CPGL; CN2; Peptidase A; HsT2298; PEPA; CNDP Dipeptidase 2 (Metallopeptidase M20 Family); Glutamate Carboxypeptidase-Like Protein 1; Cytosolic Non-Specific Dipeptidase; Cytosolic Nonspecific Dipeptidase; Carnosine Dipeptidase II; Threonyl Dipeptidase; Carnosinase-2; FLJ10830; HEL-S-13; Epididymis Secretory Protein Li 13; CNDP Dipeptidase; EC 3.4.13.18
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human CNDP2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    16F12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis.
  • 基因功能參考文獻：
    1. The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes. PMID: 28871847
    2. These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form. PMID: 29056506
    3. To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation. PMID: 25964343
    4. Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo. PMID: 24885395
    5. Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. PMID: 24395568
    6. a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation. PMID: 22410244
    7. deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer. PMID: 22128300
    8. Common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes. PMID: 21573905
    9. the crystal structure of the flop-selective allosteric modulator, PEPA, bound to the binding domains of the GluA2 and GluA3 flop isoforms of AMPA receptors PMID: 20199107
    10. Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes PMID: 18753673

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M20A family
  • 組織特異性：
    [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes. Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level).; [Isoform 2]: Bro
  • 數據庫鏈接：

    HGNC: 24437

    OMIM: 169800

    KEGG: hsa:55748

    STRING: 9606.ENSP00000325548

    UniGene: Hs.149185