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WIPI1

WD repeat domain phosphoinositide-interacting protein 1 is a protein in humans that is encoded by WIPI1 gene. Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

WIPI1 Antibodies

WIPI1 for Homo sapiens (Human)

WIPI1 Proteins

WIPI1 Proteins for Homo sapiens (Human)

WIPI1 Proteins for Xenopus laevis (African clawed frog)

WIPI1 Proteins for Mus musculus (Mouse)