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UFD1

Ubiquitin recognition factor in ER-associated degradation protein 1 is a protein in humans that is encoded by UFD1 gene. Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I

UFD1 Antibodies

UFD1 for Homo sapiens (Human)

UFD1 Proteins

UFD1 Proteins for Mus musculus (Mouse)

UFD1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UFD1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

UFD1 Proteins for Dictyostelium discoideum (Slime mold)

UFD1 Proteins for Homo sapiens (Human)

UFD1 Proteins for Rattus norvegicus (Rat)