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TFF1

TFF1,全稱為轉(zhuǎn)鐵蛋白受體樣因子1(Trefoil factor 1),是一種主要由胃腸道黏膜細(xì)胞產(chǎn)生的蛋白質(zhì),也被稱為pS2或MUC21。TFF1蛋白在維持胃腸道黏膜的完整性方面發(fā)揮著重要作用,它能夠增強(qiáng)黏液凝膠的穩(wěn)定性,為胃腸道提供重要的物理屏障,保護(hù)其免受潛在傷害。此外,TFF1蛋白還參與傷口愈合過(guò)程,通過(guò)加速傷口愈合來(lái)局部抵抗炎癥和胃腸道損傷。在疾病方面,TFF1蛋白的表達(dá)水平與多種胃腸道疾病相關(guān),如炎癥性腸病、胃癌等。目前,針對(duì)TFF1蛋白的藥物研發(fā)也在進(jìn)行中,例如一些靶向TFF1的單克隆抗體藥物已進(jìn)入臨床試驗(yàn)階段,用于治療炎癥性腸病等疾病。

熱銷產(chǎn)品

Recombinant Human Trefoil factor 1 (TFF1) (CSB-EP023431HU)

驗(yàn)證數(shù)據(jù)

CSB-EP023431HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP023431HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023431HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TFF1.

CSB-EP023431HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023431HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TFF1.

TFF1 Recombinant Monoclonal Antibody (CSB-RA844006A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA844006A0HU

Immunofluorescence staining of HepG2 cell with CSB-RA844006A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA844006A0HU

Overlay Peak curve showing MCF-7 cells stained with CSB-RA844006A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

TFF1 Antibodies

TFF1 for Homo sapiens (Human)

TFF1 Proteins

TFF1 Proteins for Homo sapiens (Human)

TFF1 Proteins for Rattus norvegicus (Rat)

TFF1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TFF1 Proteins for Mus musculus (Mouse)