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SERPINE1

SERPINE1,即絲氨酸蛋白酶抑制劑家族E成員1,別名PAI-1、PLANH1,是一種由人體基因SERPINE1編碼的分泌型糖蛋白,屬于絲氨酸蛋白酶抑制劑超家族中的一員,主要在血管內(nèi)皮細胞中產(chǎn)生,但也可在其他組織如脂肪組織中分泌。
SERPINE1通過抑制尿激酶和組織型纖溶酶原激活劑(uPA和tPA)的活性,從而調(diào)節(jié)凝血與纖溶系統(tǒng)。
SERPINE1參與多種生理和病理過程,包括纖維蛋白溶解、纖維化、血管生成、傷口愈合以及腫瘤細胞的侵襲和轉(zhuǎn)移。異常的SERPINE1表達與多種疾病相關(guān),如代謝綜合征、哮喘、重度抑郁癥以及衰老相關(guān)疾病,且與血栓形成傾向有關(guān)。

熱銷產(chǎn)品

Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1), partial (CSB-EP021081HU1e0)

驗證數(shù)據(jù)

CSB-EP021081HU1e0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SERPINE1 Recombinant Monoclonal Antibody (CSB-RA156066A0HU)

驗證數(shù)據(jù)

CSB-RA156066A0HU

Western Blot
Positive WB detected in: U-251 whole cell lysate, U-87 whole cell lysate
All lanes: PAI1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 44 kDa
Observed band size: 45 kDa

CSB-RA156066A0HU

IHC image of CSB-RA156066A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

SERPINE1 Antibodies

SERPINE1 for Homo sapiens (Human)

SERPINE1 Proteins

SERPINE1 Proteins for Sus scrofa (Pig)

SERPINE1 Proteins for Bos taurus (Bovine)

SERPINE1 Proteins for Mus musculus (Mouse)

SERPINE1 Proteins for Homo sapiens (Human)

SERPINE1 Proteins for Rattus norvegicus (Rat)

SERPINE1 Proteins for Mustela vison (American mink) (Neovison vison)

SERPINE1 ELISA Kit

SERPINE1 ELISA Kit for Homo sapiens (Human)

SERPINE1 ELISA Kit for Mus musculus (Mouse)

SERPINE1 ELISA Kit for Sus scrofa (Pig)

SERPINE1 ELISA Kit for Rattus norvegicus (Rat)