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Your Good Partner in Biology Research

RAMP2

RAMP2,全名為受體活性修飾蛋白2,常見別名為Calcitonin-receptor-like receptor activity-modifying protein 2或CRLR activity-modifying protein 2。該蛋白主要與CGRP受體(降鈣素基因相關(guān)肽受體)結(jié)合,形成異源二聚體,參與多種生理功能。RAMP2在神經(jīng)系統(tǒng)中發(fā)揮重要作用,與偏頭痛、青光眼等疾病密切相關(guān)。研究表明,RAMP2的表達(dá)異常可能與高氧肺損傷有關(guān),其調(diào)控機(jī)制有助于理解疾病的發(fā)生發(fā)展。在藥物研發(fā)方面,針對(duì)RAMP2的拮抗劑和激動(dòng)劑已被開發(fā)用于治療偏頭痛和降糖減重等疾病。例如,Vazegepant是一種口服有效的CGRP受體拮抗劑,通過抑制RAMP2與CGRP受體的結(jié)合,緩解偏頭痛癥狀。此外,RAMP2基因敲除細(xì)胞株為藥物研發(fā)提供了重要工具,有助于探索新型治療策略。未來,RAMP2相關(guān)藥物的研發(fā)有望為相關(guān)疾病的治療帶來更多突破。

熱銷產(chǎn)品

RAMP2 Antibody (CSB-PA019305LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA019305LA01HU

IHC image of CSB-PA019305LA01HU diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA019305LA01HU

Immunofluorescence staining of A549 cells with CSB-PA019305LA01HU at 1:230, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RAMP2 Antibodies

RAMP2 for Homo sapiens (Human)

RAMP2 Proteins

RAMP2 Proteins for Homo sapiens (Human)

RAMP2 Proteins for Cavia porcellus (Guinea pig)

RAMP2 Proteins for Rattus norvegicus (Rat)

RAMP2 Proteins for Mus musculus (Mouse)