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L1CAM

L1CAM,全稱 neural cell adhesion molecule L1,是一種廣泛表達于神經系統中的細胞粘附分子。它也被稱為CD171、L1、S10、MIC5等。L1CAM蛋白在神經元遷移、軸突生長、突觸形成等過程中發揮重要作用,參與構建神經網絡的精細結構。研究表明,L1CAM蛋白與多種疾病的發生發展密切相關,包括癌癥、神經退行性疾病等。因此,針對L1CAM蛋白的藥物研發成為近年來研究的熱點。目前,已有多種靶向L1CAM蛋白的藥物進入臨床試驗階段,顯示出在癌癥治療方面的潛力。

熱銷產品

Recombinant Human Neural cell adhesion molecule L1 (L1CAM), partial (Active) (CSB-MP012704HU1)

驗證數據

CSB-MP012704HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012704HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized L1CAM at 2 μg/ml can bind Anti-L1CAM Rabbit Monoclonal Antibody (CSB-RA595071A0HU), the EC50 is 5.384-9.380 ng/ml.

Recombinant Mouse Neural cell adhesion molecule L1 (L1cam), partial (Active) (CSB-MP012704MO)

驗證數據

CSB-MP012704MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012704MO

Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse L1cam at 2 μg/ml can bind Anti-L1CAM recombinant antibody(CSB-RA012704MA1HU). The EC50 is 1.827-2.141 ng/mL.

CSB-MP012704MO

The purity of L1cam was greater than 95% as determined by SEC-HPLC

Recombinant Macaca fascicularis Neural cell adhesion molecule L1 (L1CAM), partial (Active) (CSB-MP6775MOV)

驗證數據

CSB-MP6775MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP6775MOV

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis L1CAM at 2 μg/ml can bind Anti-L1CAM recombinant antibody(CSB-RA012704MA1HU). The EC50 is 1.496-1.709 ng/mL.

CSB-MP6775MOV

The purity of L1CAM was greater than 95% as determined by SEC-HPLC

L1CAM Recombinant Monoclonal Antibody (CSB-RA588962A0HU)

驗證數據

CSB-RA588962A0HU

IHC image of CSB-RA588962A0HU diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.76% DAB.

CSB-RA588962A0HU

Overlay Peak curve showing MCF-7 cells stained with CSB-RA588962A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

L1CAM Antibody (CSB-PA07439A0Rb)

驗證數據

CSB-PA07439A0Rb

Western Blot
Positive WB detected in: Hela whole cell lysate, NIH/3T3 whole cell lysate
All lanes: L1CAM antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 141, 140, 139 kDa
Observed band size: 90 kDa

CSB-PA07439A0Rb

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA07439A0Rb at dilution of 1:100

CSB-PA07439A0Rb

Immunofluorescent analysis of A549 cells using CSB-PA07439A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

L1CAM Antibodies

L1CAM for Homo sapiens (Human)

L1CAM Proteins

L1CAM Proteins for Mus musculus (Mouse)

L1CAM Proteins for Homo sapiens (Human)

L1CAM Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

L1CAM ELISA Kit

L1CAM ELISA Kit for Homo sapiens (Human)