KIR2DL3
KIR2DL3，全稱殺傷細(xì)胞免疫球蛋白樣受體2DL3，是一種存在于自然殺傷細(xì)胞表面的蛋白，屬于免疫球蛋白超家族。該蛋白常見別名為CD158b2、NKAT-2等，主要通過與HLA-C等位基因（如HLA-Cw1、HLA-Cw3和HLA-Cw7）相互作用，抑制NK細(xì)胞的活性，從而阻止細(xì)胞裂解。KIR2DL3在免疫調(diào)節(jié)中扮演重要角色，其表達(dá)的多態(tài)性與多種疾病相關(guān)，包括癌癥和自身免疫性疾病。近年來，針對KIR2DL3的藥物研發(fā)取得了一定進(jìn)展，例如有抗體藥物可阻斷KIR2DL1-3，提高AML急變期的NK細(xì)胞毒性和ADCC反應(yīng)。此外，也有針對KIR3DL2的藥物在研發(fā)中，主要應(yīng)用于腫瘤和自身免疫性疾病治療。KIR2DL3相關(guān)的研究為免疫治療提供了新的思路，未來有望在疾病診斷和治療中發(fā)揮更大作用。
熱銷產(chǎn)品
KIR2DL3 Antibody (CSB-PA012354LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012354LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA012354LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
KIR2DL3 Antibodies
KIR2DL3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012354GA01HU | KIR2DL3 Antibody | Human | ELISA,WB |
| CSB-PA913411 | KIR2DL3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA012354LA01HU | KIR2DL3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA012354LB01HU | KIR2DL3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012354LC01HU | KIR2DL3 Antibody, FITC conjugated | Human | |
| CSB-PA012354LD01HU | KIR2DL3 Antibody, Biotin conjugated | Human | ELISA |
KIR2DL3 Proteins
KIR2DL3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012354HU1 CSB-EP012354HU1 CSB-BP012354HU1 CSB-MP012354HU1 CSB-EP012354HU1-B |
Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012354HU | Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) | in vitro E.coli expression system |
