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KCNN4

KCNN4,全稱為Intermediate conductance calcium-activated potassium channel protein 4,常見別名包括SKCa 4、SKCa4、rSK4等。該蛋白屬于鉀離子通道,能夠介導細胞膜上鉀離子的電壓非依賴性轉移。KCNN4蛋白的激活依賴于細胞內鈣離子的濃度增加,其激活后能夠引起細胞膜超極化,進而促進鈣離子的內流。KCNN4蛋白在多種生理過程中發揮重要作用,包括血管收縮、神經細胞興奮性調節、細胞體積穩態維持等。研究表明,KCNN4蛋白與多種疾病密切相關,如高血壓、心律失常、神經退行性疾病等。目前,針對KCNN4蛋白的藥物研發已取得一定進展,例如,有研究開發了一種能夠抑制KCNN4蛋白活性的小分子化合物,該化合物在治療高血壓和心律失常方面展現出良好的前景。此外,KCNN4蛋白還被認為是自身免疫性疾病的潛在治療靶點,相關藥物研發也在進行中。

熱銷產品

Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4) (CSB-CF012086HU)

驗證數據

CSB-CF012086HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.

CSB-CF012086HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.

KCNN4 Antibody (CSB-PA012086ESR2HU)

驗證數據

CSB-PA012086ESR2HU

Western blot
All lanes: KCNN4 antibody at 8µg/ml + human serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa

CSB-PA012086ESR2HU

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA012086ESR2HU at dilution of 1:100

CSB-PA012086ESR2HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012086ESR2HU at dilution of 1:100

CSB-PA012086ESR2HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012086ESR2HU at dilution of 1:100

KCNN4 Antibodies

KCNN4 for Homo sapiens (Human)

KCNN4 Proteins

KCNN4 Proteins for Homo sapiens (Human)

KCNN4 Proteins for Mus musculus (Mouse)

KCNN4 Proteins for Rattus norvegicus (Rat)