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IDO1

IDO1,即吲哚胺2,3-雙加氧酶1,它是一種由IDO1基因編碼的酶,主要分布在肝臟外的各種組織和細胞中,如胸腺、小腸、附睪、胎盤、腎臟、脾臟、胰腺、中樞神經系統等。IDO1的主要作用機制是催化色氨酸轉化為犬尿氨酸,這一過程是色氨酸代謝的限速步驟。在信號通路方面,IDO1的活性受到多種細胞因子如IFN-γ、TNF-α的調控,這些細胞因子通過作用于IDO1基因的干擾素刺激反應元素(GAS)和干擾素激活位點(ISRE)來誘導IDO1的表達。在生物學意義上,IDO1在維持免疫穩態、調節免疫應答中發揮重要作用,尤其是在妊娠期間防止胎兒排斥反應、腫瘤免疫逃逸、以及某些感染性疾病中。IDO1的異常表達或活性與多種疾病包括腫瘤、自身免疫病和神經退行性疾病等的發生發展密切相關。

熱銷產品

Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) (CSB-EP010996HU)

驗證數據

CSB-EP010996HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP010996HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.

CSB-EP010996HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.

IDO1 Recombinant Monoclonal Antibody (CSB-RA215054A0HU)

驗證數據

CSB-RA215054A0HU

IHC image of CSB-RA215054A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Mouse Indoleamine 2,3-dioxygenase 1(IDO1) ELISA kit (CSB-EL010996MO)

驗證數據

CSB-EL010996MO 標準曲線

貨號:CSB-EL010996MO

規格:96T/48T

靈敏度:15.6 pg/mL

檢測范圍:62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IDO1 Antibodies

IDO1 for Homo sapiens (Human)

IDO1 Proteins

IDO1 Proteins for Homo sapiens (Human)

IDO1 ELISA Kit

IDO1 ELISA Kit for Homo sapiens (Human)