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FABP4

FABP4,全稱為脂肪酸結合蛋白4,也被稱為脂肪細胞脂肪酸結合蛋白(aP2)、422/aP2、AFABP、ALBP、ALBP/Ap2、Ap2、Lbpl、P15等,是一種主要在脂肪細胞中表達的脂質轉運蛋白。它負責將長鏈脂肪酸和視黃酸轉運至細胞核內各自的受體,在脂質和視黃酸轉運中發揮著關鍵作用。FABP4與其他細胞因子、炎癥介質、腫瘤組織等共同構成腫瘤微環境,通過激活核因子κB和c-Jun n-末端激酶途徑調節炎性反應,并促進脂肪分解和抑制脂肪生成。此外,FABP4還介導腫瘤相關巨噬細胞和脂肪細胞的代謝和炎癥反應,進而影響腫瘤的進展。
FABP4與肥胖、代謝疾病和心臟疾病密切相關。在肥胖人群中,FABP4的水平較高,與肥胖、代謝疾病和心臟疾病的發生發展有關。研究表明,FABP4可能成為肥胖相關乳腺癌診療的新方向,其在乳腺癌早期診療、預測預后及治療等方面具有應用前景。目前,已有多種靶向FABP4的抑制劑,如小分子抑制劑和si-RNA等,但尚無抑制劑應用于臨床。未來,加大對FABP4的相關研究及藥物開發和相關臨床試驗,將為治療癌癥患者提供新的選擇,改善患者的預后。

熱銷產品

Recombinant Human Fatty acid-binding protein, adipocyte (FABP4) (CSB-EP007945HU)

驗證數據

CSB-EP007945HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FABP4 Antibody (CSB-PA007945LA01HU)

驗證數據

CSB-PA007945LA01HU

Western Blot
Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, U87 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: FABP4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 kDa
Observed band size: 15 kDa

CSB-PA007945LA01HU

IHC image of CSB-PA007945LA01HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.

FABP4 Antibodies

FABP4 for Homo sapiens (Human)

FABP4 Proteins

FABP4 Proteins for Rattus norvegicus (Rat)

FABP4 Proteins for Homo sapiens (Human)

FABP4 Proteins for Bos taurus (Bovine)

FABP4 Proteins for Mus musculus (Mouse)

FABP4 Proteins for Sus scrofa (Pig)

FABP4 Proteins for Cervus elaphus (Red deer)

FABP4 Proteins for Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)

FABP4 ELISA Kit

FABP4 ELISA Kit for Homo sapiens (Human)

FABP4 ELISA Kit for Mus musculus (Mouse)

FABP4 ELISA Kit for Rattus norvegicus (Rat)