CSPG4
CSPG4全稱為硫酸軟骨素蛋白聚糖4（Chondroitin Sulfate Proteoglycan 4），又名神經(jīng)膠質(zhì)抗原NG2或黑色素瘤相關(guān)硫酸軟骨素蛋白聚糖（MCSP），是一種跨膜糖蛋白。其結(jié)構(gòu)包含可結(jié)合硫酸軟骨素鏈的胞外區(qū)域，廣泛表達(dá)于血管周細(xì)胞及多種惡性腫瘤細(xì)胞表面，尤其在黑色素瘤、膠質(zhì)瘤、乳腺癌中異常高表達(dá)。CSPG4通過(guò)調(diào)控細(xì)胞與微環(huán)境的相互作用，促進(jìn)腫瘤細(xì)胞遷移、侵襲及血管生成，其活性與整合素、生長(zhǎng)因子受體等分子存在交叉對(duì)話，影響MAPK、PI3K-AKT等促生存信號(hào)通路的激活。
CSPG4的過(guò)表達(dá)與腫瘤復(fù)發(fā)、耐藥性及不良預(yù)后密切相關(guān)，成為實(shí)體瘤治療的熱門靶點(diǎn)。基于此開(kāi)發(fā)的靶向藥物包括單克隆抗體（如mAb 9.2.27）、抗體藥物偶聯(lián)物以及CAR-T細(xì)胞療法，其中部分已進(jìn)入黑色素瘤的臨床試驗(yàn)階段。CSPG4在創(chuàng)傷修復(fù)和纖維化疾病中的作用也受到關(guān)注，例如肺纖維化模型中CSPG4陽(yáng)性周細(xì)胞的異常活化可能加劇組織損傷。盡管靶向CSPG4的療法尚未上市，但其在腫瘤微環(huán)境中的樞紐地位為聯(lián)合用藥提供了新思路。
熱銷產(chǎn)品
Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial (CSB-MP006076HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSPG4 Antibody (CSB-PA006076ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: CSPG4 antibody at 2.51µg/ml + A375 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 251 kDa
Observed band size: 251 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA006076ESR1HU at dilution of 1:100
Human Chondroitin sulfate proteoglycan 4(CSPG4) ELISA kit (CSB-EL006076HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL006076HU
規(guī)格：96T/48T
靈敏度：6.25 pg/mL
檢測(cè)范圍：25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSPG4 Antibodies
CSPG4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006076GA01HU | CSPG4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA575237 | CSPG4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006076ESR1HU | CSPG4 Antibody | Human | ELISA, WB, IHC |
CSPG4 Proteins
CSPG4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006076HU CSB-EP006076HU CSB-BP006076HU CSB-EP006076HU-B |
Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP006076HU | Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial | Mammalian cell |
CSPG4 ELISA Kit
CSPG4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006076HU | Human Chondroitin sulfate proteoglycan 4(CSPG4) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
