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Your Good Partner in Biology Research

BRD4

BRD4,即溴結構域蛋白4,別名BRD4。BRD4是一種屬于溴結構域和超末端結構域(BET)家族的蛋白,主要通過識別乙酰化組蛋白來調節基因表達。BRD4的作用機制主要涉及其與轉錄因子的相互作用。BRD4通過其兩個溴結構域(BD1和BD2)結合乙酰化的組蛋白,定位于目標基因的啟動子或增強子區域,促進相關基因的轉錄。此外,BRD4還通過招募轉錄延伸因子和其他調節因子,增強RNA聚合酶II的活性,從而促進基因的轉錄伸長。BRD4在細胞周期、增殖和凋亡等生理過程中起著關鍵作用。研究表明,BRD4的異常表達與多種惡性腫瘤的發生發展相關,包括急性髓系白血病、多發性骨髓瘤、乳腺癌和膠質母細胞瘤等。BRD4不僅參與腫瘤細胞的增殖和轉移,還在DNA損傷修復和端粒維持中發揮重要作用。因此,BRD4成為了癌癥治療的一個重要靶點。

熱銷產品

Recombinant Human Bromodomain-containing protein 4 (BRD4), partial (CSB-EP002802HU)

驗證數據

CSB-EP002802HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BRD4 Recombinant Monoclonal Antibody (CSB-RA152430A0HU)

驗證數據

CSB-RA152430A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: BRD4 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 153, 81, 89 kDa
Observed band size: 153 kDa

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

BRD4 Antibodies

BRD4 for Homo sapiens (Human)

BRD4 Proteins

BRD4 Proteins for Homo sapiens (Human)

BRD4 Proteins for Mus musculus (Mouse)

BRD4 ELISA Kit

BRD4 ELISA Kit for Homo sapiens (Human)