ACE2
血管緊張素轉(zhuǎn)化酶2（ACE2），也稱為ACEH，一種金屬蛋白酶，全長805個氨基酸，是具有單一胞外催化結(jié)構(gòu)域的I型跨膜糖蛋白。ACE2組織分布具有器官特異性，主要表達于腎臟、心血管及胃腸道系統(tǒng)，在正常肺組織中，Ⅰ型及Ⅱ型肺泡上皮細胞中均存在ACE2。ACE2不僅在心血管系統(tǒng)中發(fā)揮了重要的功能，而且作為SARS-CoV-2入胞的受體在肺部疾病中發(fā)揮了一定作用。研究已經(jīng)進一步證實：對于SARS-CoV-2而言，刺突蛋白（S蛋白）是介導(dǎo)病毒入侵宿主細胞的關(guān)鍵蛋白。SARS-CoV-2是通過Ｓ蛋白與ACE2結(jié)合入侵肺部細胞。ACE2與新冠病毒的RBD（受體結(jié)合結(jié)構(gòu)域）之間的親和力，比其與SARS病毒的RBD的親和力高10到20倍。隨著ACE2為SARS-CoV-2入侵人體靶點的揭露，阻斷病毒和 ACE2的結(jié)合成為了治療方向之一。
更多相關(guān)閱讀：
ACE2—新型冠狀病毒入侵人體的靶標
戰(zhàn)疫時刻|再談ACE2——新冠肺炎的“導(dǎo)火線”和“滅火器”
重大發(fā)現(xiàn)|首個不依賴于ACE2的新冠病毒新受體——AXL
熱銷產(chǎn)品
● Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial (Active) CSB-MP866317HU
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD (CSB-YP3324GMY1) at 5 μg/ml can bind human ACE2, the EC50 of human ACE2 protein is 31.80 - 44.69 ng/ml.
SARS-CoV-2 Spike protein RBD his/sumostar tag (CSB-YP3324GMY1) captured on COOH chip can bind Human ACE2 protein Fc tag (CSB-MP866317HU) with an affinity constant of 100 nM as detected by LSPR Assay.
● Recombinant Macaca fascicularis Angiotensin-converting enzyme(ACE2),partial (Active) CSB-MP3414MOV
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD (CSB-MP3324GMY1b1) at 5 μg/ml can bind Cynomolgus-ACE2, the EC50 is 5.638-9.496 ng/ml.
● Recombinant Paguma larvata Angiotensin-converting enzyme 2(ACE2),partial (Active) CSB-MP684964PAL
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD (CSB-MP348663HQE) at 2 μg/ml can bind Paguma larvata ACE2, the EC50 is 5.056-7.559 ng/ml.
Activity: Recombinant Paguma larvata ACE2 protein (CSB-MP684964PAL) enzyme activity is
Activity: Measured by its ability to cleave fluorogenic peptide substrate(Mca-Ala-Pro-Lys(Dnp)-OH), The Km is 22.84 μM.
The purity of ACE2 was greater than 90% as determined by SEC-HPLC
ACE2 Antibodies
ACE2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001150GA01HU | ACE2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA040178 | ACE2 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA111496 | ACE2 Antibody | Human | ELISA,IHC |
| CSB-PA025395 | ACE2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA445794 | ACE2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA866317LA01HU | ACE2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA866317LB01HU | ACE2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA866317LC01HU | ACE2 Antibody, FITC conjugated | Human | |
| CSB-PA866317LD01HU | ACE2 Antibody, Biotin conjugated | Human | ELISA |
ACE2 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA688690OA01RA | Ace2 Antibody | Rat | ELISA, WB |
| CSB-PA688690OB01RA | Ace2 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA688690OC01RA | Ace2 Antibody, FITC conjugated | Rat | |
| CSB-PA688690OD01RA | Ace2 Antibody, Biotin conjugated | Rat | ELISA |
ACE2 Proteins
ACE2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP325032SVG CSB-EP325032SVG CSB-BP325032SVG CSB-MP325032SVG CSB-EP325032SVG-B |
Recombinant Saccharomyces cerevisiae Metallothionein expression activator (ACE2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP519378SXV CSB-EP519378SXV CSB-BP519378SXV CSB-MP519378SXV CSB-EP519378SXV-B |
Recombinant Schizosaccharomyces pombe Metallothionein expression activator (ace2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP681966CA CSB-EP681966CA CSB-BP681966CA CSB-MP681966CA CSB-EP681966CA-B |
Recombinant Cat Angiotensin-converting enzyme 2 (ACE2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Paguma larvata (Masked palm civet)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP684964PAL CSB-EP684964PAL CSB-BP684964PAL CSB-EP684964PAL-B |
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP684964PAL | Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active) | Mammalian cell |
ACE2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP688352BO CSB-EP688352BO CSB-BP688352BO CSB-MP688352BO CSB-EP688352BO-B |
Recombinant Bovine Angiotensin-converting enzyme 2 (ACE2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP688690RA CSB-EP688690RA CSB-BP688690RA CSB-MP688690RA CSB-EP688690RA-B |
Recombinant Rat Angiotensin-converting enzyme 2 (Ace2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP732822PYX CSB-EP732822PYX CSB-BP732822PYX CSB-MP732822PYX CSB-EP732822PYX-B |
Recombinant Pongo abelii Angiotensin-converting enzyme 2 (ACE2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Hypocrea jecorina (Trichoderma reesei)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP847239HYE CSB-EP847239HYE CSB-BP847239HYE CSB-MP847239HYE CSB-EP847239HYE-B |
Recombinant Hypocrea jecorina Transcription factor ACEII (ace2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP851244MO CSB-EP851244MO CSB-BP851244MO CSB-MP851244MO CSB-EP851244MO-B |
Recombinant Mouse Angiotensin-converting enzyme 2 (Ace2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ACE2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866317HU CSB-EP866317HU CSB-BP866317HU CSB-EP866317HU-B |
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP866317HU | Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active) | Mammalian cell |
| CSB-AP005671HU | Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active) | Mammalian cell |
| CSB-MP866317HU-B | Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial,Biotinylated (Active) | Mammalian cell |
| CSB-MP866317HUb0 | Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial | Mammalian cell |
ACE2 ELISA Kit
ACE2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04489h | Human Angiotensin converting enzyme 2, ACE2 ELISA Kit | serum, plasma, cell culture supernates | 0.039 ng/mL |
ACE2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17204m | Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 1.56 pg/mL |
ACE2 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14308r | Rat Angiotensin converting enzyme 2, ACE2 ELISA Kit | serum, plasma, tissue homogenates | 0.027 ng/ml |
