MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A
種屬:
Homo sapiens (Human)
蛋白長度:
full length protein
表達區域:
1-527
氨基酸序列
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS Note: The complete sequence may
include tag sequence, target protein sequence, linker sequence
and extra sequence that is translated with the protein sequence
for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant
protein is critical to your application, please explicitly
request the full and complete sequence of this protein before
ordering.
蛋白標簽:
N-terminal 10xHis-tagged
產品提供形式:
Liquid or
Lyophilized powder
Note: We will
preferentially ship the format that we have in stock, however,
if you have any special requirement for the format, please
remark your requirement when placing the order, we will prepare
according to your demand.
緩沖液:
Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件:
Store at -20°C/-80°C upon receipt, aliquoting is
necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
保質期:
The shelf life is related to many factors, storage
state,
buffer ingredients, storage temperature and the stability of the
protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C.
The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期:
Basically, we can dispatch the products out in 1-3 working days
after receiving your orders. Delivery time may differ from different
purchasing way or location, please kindly consult your local
distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in
advance
and extra fees will be charged.
注意事項:
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
基因功能參考文獻:
MAOA is a novel direct target gene of REST. Reactive oxygen species (ROS) produced by overexpressed MAOA plays an essential role in inhibiting apoptosis and activating autophagy in NED PCa cells. MAOA inhibitors significantly reduced NED and autophagy activation of PCa cells. PMID: 28402333
The low activity-related C allele of MAOA rs1137070 is associated with an increase in the sensitivity to heroin addiction. PMID: 28345608
Polymorphisms within the MAOA gene are associated with asthenozoospermia through sperm count and motility. PMID: 29602729
Expression of the two MAOA isoforms was differentially regulated by the two VNTRs located in the promoter region. PMID: 29542091
the mean methylation values of the CpG sites studied in the MAOA gene were related to smoking behavior in women. Similarly, several methylation patterns in the MAOB gene were associated with a smoking history, with each CpG site showing a remarkable sex dependence. Smoking behavior seems to be related to the genetic and epigenetic profile of MAO genes, with considerable individual and sex-related differences PMID: 28858992
The present study extends previous work in the field by demonstrating that MAOA and harsh parenting assessed in early childhood interact to not only predict antisocial behavior in early adulthood, but also predict social information processing, a well-established social-cognitive correlate of antisocial behavior. PMID: 28031080
Study demonstrated a gene-hormone interaction both on a behavioral and neural level on risk-taking in young men. MAOA-S carriers showed attenuated automatic avoidance tendencies as reflected via response times on cash-outs. While under placebo MAOA-S and MAOA-L carriers did not differ concerning their riskiness during a risk task, testosterone administration promoted risk-taking in MAOA-S carriers. PMID: 28603901
Findings underscore complex mechanisms linking genetic susceptibility and early adverse exposures. PMID: 28163169
This study demonstrated that the MAOA-uVNTR genotypes did not show a significant association with ESS scores neither on women nor on men in patient with excessive daytime sleepiness. PMID: 28181067
Depressive symptoms in schizophrenic patients may be influenced by functional gene polymorphisms, especially those implicated in serotonergic neurotransmission, sert, mao-a, and comt. PMID: 28416295
This study extends earlier findings demonstrating an interaction between MAOA genotype and prenatal nicotine exposure on aggressive behavior into young adulthood. PMID: 27300740
Anxiety and Mood were not related to the MAO-A gene polymorphisms in healthy, late reproductive-stage women. PMID: 27614969
By examining criminal proceedings in which MAOA-L genotype evidence was introduced, we explored the forensic uses of behavioral genetic science. Westlaw and LexisNexis legal databases were electronically searched for cases from 1995 to 2016 to identify court documents from cases involving the MAOA-L genotype. Evidence of the MAOA-L genotype was included in records from 11 criminal cases (9 U.S. and 2 Italian). PMID: 27823806
MAOA is a risk gene for psychiatric disorders. PMID: 26227907
High MAOA expression is associated with glioma progression. PMID: 26871599
The relationship between personality traits of postmenopausal women and the presence of the 44-bp VNTR polymorphism in the serotonin transporter (5-HTT) (SLC6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region was determined. PMID: 28670115
Post-stroke fatigue may be associated with a genetic polymorphism involving MAO-A, at least in female stroke patients. PMID: 27866207
Childhood trauma interacts with haplotypes in COMT, MAOA and MAOB, increasing risk for OCD. PMID: 27821364
Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. PMID: 28119174
brain protein levels of MAOB are normal or elevated in the three parkinsonian conditions-with MAOB increase generally associated with elevations in levels of astrocyte markers. Brain MAOA concentrations were not decreased in Parkinson's disease, progressive supranuclear palsy , or multiple system atroph with the exception of the atrophic putamen in MSA, despite loss of dopamine neurons that presumably contain this enzyme PMID: 29050386
MAOA and MAOB variants may contribute to the etiology of Attention deficit hyperactivity disorder (ADHD) in the Indo-Caucasoid population and could be responsible for higher occurrence of ADHD in the boys. PMID: 28982350
Importance of MAOA and 5-HTTLPR polymorphisms in the treatment of spousal violence and drinking in men in batterer intervention programs. PMID: 27018532
Polymorphisms of COMT (c.649G>A), MAO-A (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease PMID: 28418735
The influence of MAOA failed to reach statistical significance within any of the regression equations in predicting adult criminal behavior. PMID: 27160004
MAOA provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6. PMID: 28292438
results highlight an association of ventral striatum MAO-A level with the functional connectivity of striatal regions linked to impulsive behavior in antisocial personality disorder PMID: 26908392
No significant association was found between severe agitation and MAOA uVNTR or MAOB rs1799836 polymorphism, revealing that these individual polymorphisms in MAO genes are not related to severe agitation in subjects with schizophrenia and conduct disorder PMID: 26851573
The effects of parenting on self-control and offending are most pronounced for those who carry plasticity alleles for both MAOA and DAT1. Thus, MAOA and DAT1 may be implicated in offending because they increase the negative effects of parenting on self-control. Implications for theory are discussed. PMID: 25326468
These data suggest a close association between MAO-A-dependent reactive oxygen species generation, actin oxidation, and ventricular dysfunction. PMID: 28044091
MAOs contribute to oxidative stress in human diseased hearts with/without diabetes mellitus. PMID: 27190576
MAOA hypomethylation is a panic disorder risk marker. PMID: 27045843
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1, DRD3 and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 locus and the 5 from the MAOA locus showed significant associations with excessive alcohol consumption. PMID: 26447226
Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood maltreatment experienced, among Chinese adolescents PMID: 26945458
In a sample of Chinese Han adolescents, MAOA and COMT genes both interacted with positive parenting in their associations with reactive but not proactive aggression. PMID: 26932718
discussion of genetic and environmental factors involved in the regulation of MAO-A expression, in the contexts of neuropsychiatric function and of the regulation of neuronal survival and death (review). PMID: 25604428
These findings suggest that the interaction of DRD2 rs1079597 and MAOA rs309850 3-repeat affects smoking intensity in young Taiwanese men. PMID: 26015071
Polymorphisms in the monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) genes modify cognitive impairment and psychiatric symptoms in Huntington's disease patients. PMID: 26081309
A functional promoter polymorphism, MAOA-LPR, plays a role in determining continuity of parent-rated attention problems during adolescence PMID: 26449393
the association of SLC6A4 and MAOA genes with measures of obesity PMID: 26698543
evidence of a moderating effect of the MAOA gene on antisocial outcomes in a population-based sample of young males; higher risks for antisocial outcomes were observed in males carrying the MAOA low-frequency alleles in comparison with high-frequency allele carriers for most outcomes when exposed to violence PMID: 26494873
Results emphasize the importance of childhood as a sensitive period in which accumulating adversity might increase the vulnerability to externalizing psychopathology in MAOA-L males and MAOA-H females PMID: 25331606
These results indicate a possible impact of the MAOA-promotor polymorphism on the neurobiological modulation of aggressive behavior PMID: 26481676
Huntington disease neural cells exhibit increased Monoamine oxidase-A and Monoamine oxidases-B expression and activity PMID: 25398695
Our study substantiates the involvement of the monoamine oxidase A and 5,10-methylenetetrahydrofolate reductase polymorphisms in climacteric depression. PMID: 26620113
Study demonstrated lower brain MAO-A levels in antisocial personality disorder, support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity PMID: 26081301
These data support part of our hypothesis that NHLH2 or MAO-A polymorphism is associated with sedentary behavior. PMID: 26196864
5HTTLPR and uMAOA polymorphisms were not risk factors for depression. PMID: 26633268
Report isolation of MOA-A inhibitors from Vernonia cinerea. PMID: 25857233
The 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. PMID: 25826396
Lower spontaneous brain activity in the pons of the MAOA-L male adolescents may provide a neural mechanism by which boys with the MAOA-L genotype confers risk for impulsivity and aggression. PMID: 24971323
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相關疾病:
Brunner syndrome (BRNRS)
亞細胞定位:
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.