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  4. EXOC2 Recombinant Monoclonal Antibody

EXOC2 Recombinant Monoclonal Antibody

  • 中文名稱：
    EXOC2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA045876A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Exocyst complex component 2 expression in HepG2 cells using Exocyst complex component 2 antibody. Green, isotype control; red, Exocyst complex component 2.
    • Immunocytochemical staining of HepG2 cells with Exocyst complex component 2 antibody. Nuclei were stained blue with DAPI; Exocyst complex component 2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using Exocyst complex component 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Exocyst complex component 2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    EXOC2; Exocyst Complex Component 2; SEC5L1; Sec5; Exocyst Complex Component Sec5; FLJ11026; SEC5-Like 1 (S. Cerevisiae); SEC5-Like 1; NEDFACH; Sec5p; SEC5
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human EXOC2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    5A2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
  • 基因功能參考文獻：
    1. data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites. PMID: 26359301
    2. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PMID: 23844030
    3. We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. PMID: 22761837
    4. Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis. PMID: 21197618
    5. shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells. PMID: 20145037
    6. SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor. PMID: 12459492
    7. evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 PMID: 14525976
    8. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    9. Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. PMID: 18697830
    10. Functional study of the Drosophila homolog. PMID: 12575951

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  • 亞細胞定位：
    Midbody, Midbody ring.
  • 蛋白家族：
    SEC5 family
  • 組織特異性：
    Widely expressed with highest levels in brain and placenta.
  • 數據庫鏈接：

    HGNC: 24968

    OMIM: 615329

    KEGG: hsa:55770

    STRING: 9606.ENSP00000230449

    UniGene: Hs.484412