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  4. Mouse CD48 antigen(CD48) ELISA kit

Mouse CD48 antigen(CD48) ELISA kit

  • 中文名稱：
    小鼠CD48抗原(CD48)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004941MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠CD48抗原(CD48)酶聯(lián)免疫試劑盒（CSB-EL004941MO）檢測樣本中的CD48含量。CD48，又稱SLAMF2、BCM-1和BLAST-1，是一種GPI連接的免疫球蛋白超家族成員，主要表達于NK細胞、T細胞等。CD48作為免疫共刺激分子和黏附分子，參與免疫調(diào)節(jié)，在自身免疫、炎癥、過敏、造血及腫瘤中發(fā)揮重要作用。其研究機制涉及CD48的結(jié)構(gòu)、配體、反受體及其調(diào)節(jié)機制等。本試劑盒適用于科研領(lǐng)域，如探索免疫微環(huán)境調(diào)控、炎癥性疾病模型或腫瘤免疫相關(guān)機制，為體外實驗提供定量分析工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cd48 ELISA kit; Bcm-1CD48 antigen ELISA kit; BCM1 surface antigen ELISA kit; BLAST-1 ELISA kit; HM48-1 ELISA kit; MRC OX-45 surface antigen ELISA kit; SLAM family member 2 ELISA kit; SLAMF2 ELISA kit; Signaling lymphocytic activation molecule 2 ELISA kit; sgp-60 ELISA kit; CD antigen CD48 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 檢測范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
  • 基因功能參考文獻：
    1. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes. PMID: 25142868
    2. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD. PMID: 25255823
    3. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48. PMID: 24056518
    4. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms. PMID: 21221603
    5. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner PMID: 21561736
    6. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development PMID: 21576698
    7. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice PMID: 20647560
    8. CD48 interactions with NK cell receptor 2B4 among neighboring T cells during T cell priming augment CTL lysis of their specific targets. PMID: 12734329
    9. compare the relative contributions of MHC class I and CD48 to NK cell self-tolerance; and CD244 regulates NK cell tolerance to normal cells in vivo; evidence for MHC-independent NK self-recognition in a bone marrow rejection assay PMID: 15870174
    10. Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct hematopoietic progenitor cells. PMID: 15989959
    11. Review of recent studies suggests an important role for interactions between 2B4 and CD48 in the course of T cell activation and proliferation PMID: 16081768
    12. T cell-induced experimental colitis is ameliorated only when CD48 is absent from both T cells and antigen-presenting cells. PMID: 16472597
    13. the mechanism of signal transduction by CD244 is to regulate FYN kinase recruitment and/or activity and the outcome of CD48/CD244 interactions is determined by which other receptors are engaged. PMID: 17599905

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:12506

    STRING: 10090.ENSMUSP00000064241

    UniGene: Mm.1738