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PTPRC

PTPRC,即蛋白酪氨酸磷酸酶受體C型,它是一種跨膜蛋白酪氨酸磷酸酶,廣泛表達(dá)于T淋巴細(xì)胞、B淋巴細(xì)胞、自然殺傷細(xì)胞(NK細(xì)胞)和巨噬細(xì)胞等免疫細(xì)胞中。PTPRC通過去磷酸化作用調(diào)節(jié)多種信號傳導(dǎo)途徑,包括但不限于細(xì)胞生長、分化、有絲分裂和致癌轉(zhuǎn)化等細(xì)胞過程。它參與調(diào)控的信號通路主要有T細(xì)胞受體(TCR)和B細(xì)胞受體(BCR)的信號傳導(dǎo),通過與抗原受體復(fù)合物直接相互作用,或激活Src家族激酶,對抗原受體信號轉(zhuǎn)導(dǎo)進(jìn)行調(diào)節(jié)。此外,PTPRC還抑制JAK激酶,作為細(xì)胞因子受體信號轉(zhuǎn)導(dǎo)的調(diào)節(jié)者。在生物學(xué)意義上,PTPRC對維持免疫系統(tǒng)的正常功能至關(guān)重要,其異常表達(dá)或功能失調(diào)與多種自身免疫疾病和癌癥的發(fā)生發(fā)展有關(guān)。

熱銷產(chǎn)品

Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial (Active) (CSB-MP019049HUc7)

驗證數(shù)據(jù)

CSB-MP019049HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP019049HUc7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PTPRC protein at 2 μg/ml can bind Anti-PTPRC recombinant antibody (CSB-RA019049MA2HU). The EC50 is 25.15-29.54 ng/mL.

CSB-MP019049HUc7

The purity of PTPRC was greater than 95% as determined by SEC-HPLC

Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial (CSB-EP019049HU)

驗證數(shù)據(jù)

CSB-EP019049HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PTPRC Recombinant Monoclonal Antibody (CSB-RA019049MA1HU)

驗證數(shù)據(jù)

CSB-RA019049MA1HU

Overlay Peak curve showing 293 cells surface stained with CSB-RA019049MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

PTPRC Antibodies

PTPRC for Homo sapiens (Human)

PTPRC for H

PTPRC Proteins

PTPRC Proteins for Homo sapiens (Human)

PTPRC Proteins for Mus musculus (Mouse)

PTPRC Proteins for Rattus norvegicus (Rat)

PTPRC Proteins for Cyprinus carpio (Common carp)