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NCR3LG1

NCR3LG1,全名為自然殺傷細胞細胞毒性受體3配體1,也被稱為B7-H6或DKFZp686O24166。它是一種免疫調節蛋白,屬于B7家族基因成員,主要在腫瘤細胞表面表達,而在正常細胞中幾乎不表達。NCR3LG1通過與NK細胞表面的NKp30受體結合,激活NK細胞的殺傷活性,從而在抗腫瘤和抗感染免疫中發揮關鍵作用。研究表明,NCR3LG1在某些癌癥如白血病、淋巴瘤和實體瘤中過表達,可能通過逃避免疫監視促進腫瘤進展。相反,降低NCR3LG1表達可能減弱NK細胞的活化,影響機體對病原體和腫瘤的清除能力。此外,NCR3LG1的異常表達還與某些自身免疫性疾病和慢性炎癥相關。目前,以NCR3LG1為靶點的藥物研發主要集中在腫瘤免疫治療與感染性疾病調控領域,部分小分子及生物制劑已進入臨床驗證階段,未來有望為相關疾病的治療提供新的策略。

熱銷產品

Recombinant Human Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), partial, Biotinylated (Active) (CSB-MP737873HU-B)

驗證數據

CSB-MP737873HU-B

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP737873HU-B

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-NCR3LG1 recombinant antibody(CSB-RA737873MA1HU) at 2 μg/ml can bind Human NCR3LG1. The EC50 is 0.4364-0.5147 ng/mL.

CSB-MP737873HU-B

Activity
Measured by its binding ability in a functional ELISA. Immobilized human NCR3(CSB-MP015551HU1) at 5 μg/ml can bind Human NCR3LG1. The EC50 is 111.3-303.1 ng/mL.

CSB-MP737873HU-B

The purity of NCR3LG1 was greater than 95% as determined by SEC-HPLC

Recombinant Human Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), partial (Active) (CSB-BP737873HU)

驗證數據

CSB-BP737873HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-BP737873HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human NCR3LG1 at 2 μg/ml can bind Anti-NCR3LG1 recombinant antibody(CSB-RA737873MA1HU). The EC50 is 10.90-12.22 ng/mL.

Recombinant Human Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), partial (CSB-EP737873HU)

驗證數據

CSB-EP737873HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NCR3LG1 Recombinant Monoclonal Antibody (CSB-RA737873MA1HU)

驗證數據

CSB-RA737873MA1HU

The Binding Activity of Human NCR3LG1 with Anti-NCR3LG1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human NCR3LG1(CSB-BP737873HU) at 2 μg/mL can bind Anti-NCR3LG1 recombinant antibody. The EC50 is 10.90-12.22 ng/mL.

CSB-RA737873MA1HU

The Binding Activity of Human NCR3LG1 with Anti-NCR3LG1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-NCR3LG1 recombinant antibody at 2 μg/mL can bind Human NCR3LG1(CSB-MP737873HU-B). The EC50 is 0.4364-0.5147 ng/mL.

NCR3LG1 Antibodies

NCR3LG1 for Homo sapiens (Human)