IGHE
IGHE，即免疫球蛋白重鏈ε（IgE），屬于免疫球蛋白超家族成員。該蛋白主要參與過敏反應(yīng)和抗寄生蟲免疫。IgE蛋白作為B細胞上的膜結(jié)合受體，在特異性抗原結(jié)合后觸發(fā)B細胞的克隆擴增和分化為漿細胞，進而分泌IgE抗體。IgE抗體與肥大細胞和嗜堿性粒細胞表面的高親和力FcεRI受體結(jié)合，觸發(fā)組胺等炎癥介質(zhì)的釋放，導(dǎo)致過敏反應(yīng)的發(fā)生。此外，IgE蛋白還在抗寄生蟲免疫中發(fā)揮作用，通過與寄生蟲表面的抗原結(jié)合，激活嗜酸性粒細胞等免疫細胞，清除寄生蟲。
IGHE與多種過敏性疾病相關(guān)，如特應(yīng)性皮炎、哮喘、蕁麻疹等。此外，IGHE蛋白的低表達可能增加寄生蟲感染的風(fēng)險。目前，針對IGHE蛋白的藥物研發(fā)主要集中在過敏性疾病的治療上。例如，一些藥物可以抑制IgE抗體的產(chǎn)生或阻止IgE與FcεRI受體的結(jié)合，從而減輕過敏反應(yīng)的癥狀。此外，還有一些藥物可以增強IgE介導(dǎo)的抗寄生蟲免疫，用于治療寄生蟲感染。
熱銷產(chǎn)品
Recombinant Human Immunoglobulin heavy constant epsilon (IGHE), partial (Active) (CSB-MP1684HU3d7)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IGHE at 2 μg/ml can bind Anti-IGHE recombinant antibody (CSB-RA16849MA1HU). The EC50 is 3.097-4.487 ng/mL.
IGHE (Ligelizumab) Recombinant Monoclonal Antibody (CSB-RA16849MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Human IGHE with Anti-IGHE Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGHE (CSB-MP1684HU3d7) at 2 μg/mL can bind Anti-IGHE recombinant antibody. The EC50 is 3.097-4.487 ng/mL.
IGHE Antibodies
IGHE for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-RA16849MA1HU | IGHE (Ligelizumab) Recombinant Monoclonal Antibody | Human | ELISA |
IGHE Proteins
IGHE Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP1684HU3 CSB-EP1684HU3 CSB-BP1684HU3 CSB-MP1684HU3 CSB-EP1684HU3-B |
Recombinant Human Immunoglobulin heavy constant epsilon (IGHE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP1684HU3d7 | Recombinant Human Immunoglobulin heavy constant epsilon (IGHE), partial (Active) | Mammalian cell |
