CYP27A1
CYP27A1，即細(xì)胞色素P450家族27亞家族A成員1。別名CTX、CP27、CYP27，它是一種線粒體酶，主要在肝臟中催化膽汁酸生物合成途徑中膽固醇的27-羥基化，這一步驟是合成膽汁酸的替代途徑的關(guān)鍵步驟。CYP27A1還參與了膽固醇的27-羥化，生成27-羥基膽固醇，這種物質(zhì)可以激活肝孤兒受體并誘導(dǎo)巨噬細(xì)胞中的膽固醇流出轉(zhuǎn)運(yùn)蛋白ABCA1和ABCG1，對(duì)膽固醇的逆向轉(zhuǎn)運(yùn)和整體膽固醇穩(wěn)態(tài)具有重要作用。此外，CYP27A1還催化維生素D3的生物活化過程。CYP27A1與多種腫瘤的形成密切相關(guān)，包括乳腺癌、前列腺癌、結(jié)腸直腸癌和肝癌等。在腫瘤細(xì)胞中，CYP27A1的表達(dá)可能影響腫瘤的生長(zhǎng)和預(yù)后，其在腫瘤進(jìn)程中的作用是一個(gè)重要的研究領(lǐng)域。
熱銷產(chǎn)品
CYP27A1 Antibody (CSB-PA880560LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA880560LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880560LA01HU at dilution of 1:100
CYP27A1 Antibodies
CYP27A1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006405GA01HU | CYP27A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA695994 | CYP27A1 Antibody | Human | ELISA,WB |
| CSB-PA001944 | CYP27A1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA446866 | CYP27A1 Antibody | Human | ELISA,IHC |
| CSB-PA033966 | CYP27A1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA880560LA01HU | CYP27A1 Antibody | Human | ELISA, IHC |
CYP27A1 Proteins
CYP27A1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006405RB CSB-EP006405RB CSB-BP006405RB CSB-MP006405RB CSB-EP006405RB-B |
Recombinant Rabbit Sterol 26-hydroxylase, mitochondrial (CYP27A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CYP27A1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP880560MO CSB-EP880560MO CSB-BP880560MO CSB-MP880560MO CSB-EP880560MO-B |
Recombinant Mouse Sterol 26-hydroxylase, mitochondrial (Cyp27a1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
