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Your Good Partner in Biology Research

CTSL

組織蛋白酶L(CTSL)是一種在人體內(nèi)發(fā)揮重要作用的蛋白酶。它的全稱是cathepsin L,常見的別名包括CTSL1和MEP。CTSL蛋白主要存在于溶酶體中,負(fù)責(zé)細(xì)胞內(nèi)蛋白質(zhì)的分解代謝。它能夠水解多種底物,包括膠原蛋白、彈性蛋白和α-1蛋白酶抑制劑等,這些底物與多種生理過(guò)程密切相關(guān)。例如,CTSL參與抗原加工和提呈,這對(duì)于免疫系統(tǒng)的正常運(yùn)作至關(guān)重要;它還與細(xì)胞凋亡、細(xì)胞分化以及腫瘤的發(fā)生發(fā)展有關(guān)。研究表明,CTSL在多種疾病中發(fā)揮作用,包括癌癥、心血管疾病和神經(jīng)系統(tǒng)疾病等。因此,CTSL成為藥物研發(fā)的重要靶點(diǎn)。目前,已有多種CTSL抑制劑被開發(fā)出來(lái),用于治療癌癥、病毒感染等疾病。其中,Phelix Therapeutics公司研發(fā)的cathepsin L inhibitors是一種針對(duì)CTSL的小分子藥物,正在用于治療冠狀病毒感染。此外,還有研究表明,CTSL抑制劑在抗腫瘤、抗病毒等方面具有潛在的應(yīng)用價(jià)值。

熱銷產(chǎn)品

Recombinant Human Procathepsin L (CTSL) (Active) (CSB-MP006193HU(A4))

驗(yàn)證數(shù)據(jù)

CSB-MP006193HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006193HU(A4)

Activity
Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC, The specific activity is >32000 pmol/ min/μg.

CTSL Recombinant Monoclonal Antibody (CSB-RA006193MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA006193MA1HU

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA006193MA1HU

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA006193MA1HU

Immunofluorescence staining of NIH/3T3 cell with CSB-RA006193MA1HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CTSL Antibody (CSB-PA11499A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA11499A0Rb

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA11499A0Rb at dilution of 1:100

CSB-PA11499A0Rb

Immunofluorescent analysis of HepG2 cells using CSB-PA11499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CTSL Antibodies

CTSL for Chlorocebus aethiops

CTSL for Homo sapiens (Human)

CTSL Proteins

CTSL Proteins for Felis catus (Cat) (Felis silvestris catus)

CTSL Proteins for Bos taurus (Bovine)

CTSL Proteins for Mus musculus (Mouse)

CTSL Proteins for Rattus norvegicus (Rat)

CTSL Proteins for Homo sapiens (Human)

CTSL Proteins for Gallus gallus (Chicken)

CTSL Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CTSL Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CTSL Proteins for Ovis aries (Sheep)

CTSL Proteins for Sus scrofa (Pig)

CTSL ELISA Kit

CTSL ELISA Kit for Homo sapiens (Human)

CTSL ELISA Kit for Mus musculus (Mouse)

CTSL ELISA Kit for Rattus norvegicus (Rat)