ADAM9

ADAM9（A disintegrin and metalloprotease 9），即含有脫氨酸和金屬蛋白酶結(jié)構(gòu)域的蛋白9，是一種多功能的膜錨定蛋白，參與了多種生理過程。它由信號(hào)肽、金屬蛋白酶結(jié)構(gòu)域、脫氨酸結(jié)構(gòu)域、富含半胱氨酸的結(jié)構(gòu)域和類表皮生長(zhǎng)因子樣結(jié)構(gòu)域組成。ADAM9在高爾基體運(yùn)輸至細(xì)胞膜的過程中，通過去除其抑制性原結(jié)構(gòu)域而被激活，這一裂解過程由furin或前蛋白轉(zhuǎn)化酶在兩個(gè)PC位點(diǎn)進(jìn)行。ADAM9的功能涉及細(xì)胞粘附、細(xì)胞表面蛋白的脫落，以及在發(fā)育、炎癥和退行性疾病中的作用。特別地，ADAM9在腫瘤生物學(xué)中扮演著關(guān)鍵角色，其在多種癌癥中的過表達(dá)與腫瘤的侵襲性和不良預(yù)后密切相關(guān)。ADAM9通過蛋白水解和非蛋白水解途徑促進(jìn)腫瘤的進(jìn)展、治療抗性和轉(zhuǎn)移。它能夠識(shí)別并釋放膜結(jié)合的細(xì)胞因子和生長(zhǎng)因子的胞外片段，同時(shí)參與受體和其他分子的信號(hào)轉(zhuǎn)導(dǎo)。ADAM9在腫瘤增殖、血管生成和免疫逃逸等多個(gè)腫瘤過程中發(fā)揮作用。因此，ADAM9已成為炎癥性疾病和癌癥治療中的潛在生物標(biāo)志物和治療靶點(diǎn)，針對(duì)其的治療策略包括ADC藥物、單克隆抗體和小分子抑制劑等正在開發(fā)中。

熱銷產(chǎn)品

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9),Partial (Active) (CSB-MP618774HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU). The EC₅₀ is 0.9401-1.088 ng/mL.

Recombinant Macaca fascicularis ADAM metallopeptidase domain 9 (ADAM9), partial (Active) (CSB-MP7133MOVd7)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU).The EC₅₀ is 1.329-1.813 ng/mL.

ADAM9 Antibody (CSB-PA618774ESR1HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: Disintegrin and metalloproteinase domain-containing protein 9 antibody at 2μg/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 91, 73 kDa
Observed band size: 91 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA618774ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618774ESR1HU at dilution of 1:100

ADAM9 Antibody

ADAM9 Protein

ADAM9 ELISA Kit

ADAM9 Antibodies

ADAM9 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA618774ESR1HU	ADAM9 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA618774ESR2HU	ADAM9 Antibody	Human	ELISA, IHC
CSB-RA618774MA1HU	ADAM9 (izeltabart) Recombinant Monoclonal Antibody	Human	ELISA

ADAM9 Proteins

ADAM9 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP618774HU CSB-EP618774HU CSB-BP618774HU CSB-EP618774HU-B	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP618774HU	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9),Partial (Active)	Mammalian cell
CSB-MP618774HU1	Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Partial	Mammalian cell

ADAM9 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP730719MO CSB-EP730719MO CSB-BP730719MO CSB-EP730719MO-B	Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 9 (Adam9), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli